Orphan GPCR research
نویسندگان
چکیده
منابع مشابه
An orphan GPCR finds a home in the heart.
G PROTEIN-COUPLED RECEPTORS (GPCRs) are the largest and most successful targets for pharmacotherapy to date, particularly in the area of cardiovascular disease. These receptors are at the forefront of current drug discovery efforts (7). GPCRs also form the largest family of transmembrane receptors, with nearly 800 GPCR loci (12, 18), of which several hundred are categorized as orphan GPCRs. The...
متن کاملModel organisms in GPCR research
Institute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany (T.L.), Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA (M.M.B.), Department of Anesthesiology, Division of Basic Research and Washington University Pain Center and Department of Anatomy and Neurobiology and Division of Biological and Biomedical Sciences, Wa...
متن کاملDevelopment of new in silico methods to identify ligands for orphan GPCR
In the first step of our procedure, ligand-based, as well as receptor-based fingerprints are constructed. The receptorfingerprints are based on the physico-chemical properties of residues lining the transmembrane cavities of GPCR homology models [1,2]. The ligand-fingerprints are derived from Shannon Entropy of pairwise distributions of atom properties. In a second step, the two fingerprints ar...
متن کاملThe Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse
Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. They are the second largest subfamily of seven-transmembrane spanning proteins in vertebrates, but the function of most of these receptors is still not understood. The orphan Adhesion-GPCR GP...
متن کاملElucidation of signaling and functional activities of an orphan GPCR, GPR81.
GPR81 is an orphan G protein-coupled receptor (GPCR) that has a high degree of homology to the nicotinic acid receptor GPR109A. GPR81 expression is highly enriched and specific in adipocytes. However, the function and signaling properties of GPR81 are unknown because of the lack of natural or synthetic ligands. Using chimeric G proteins that convert Gi-coupled receptors to Gq-mediated inositol ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2008
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0707606